BiologybioRxiv
Ranked by formulaVerdict: NotablePhenologs at knowledge-graph scale: a mouse-to-slime-mold catalog of candidate genes for thousands of human diseases
Model organisms carry decades of systematic gene-phenotype annotation, but connecting those annotations to human disease is rarely straightforward.
Key numbers
- 23.5 times the random-gene expectation
- 5% false discovery rate estimated
Caveats
- Preprint; not yet peer reviewed.
VerdictWorth a reader's time today.
Abstract
Model organisms carry decades of systematic gene-phenotype annotation, but connecting those annotations to human disease is rarely straightforward. Phenologs offer a principled way to bridge this gap. A human disease and a model-organism phenotype are phenologs when their associated genes, linked by orthology, overlap more than expected by chance, so the genes of one become candidates for the other. Here we compute phenologs from the Monarch Knowledge Graph, which integrates gene-disease, gene-phenotype and orthology data for human and seven model species. Using PANTHER protein families as orthogroups and a 5% false discovery rate estimated from 1,000 randomized networks, we identify 61,243 phenologs between 3,752 human diseases and 9,700 model-organism phenotypes. We introduce a hypergeometric scheme for ranking the candidate genes a disease's phenologs nominate and compare it with the naive Bayes scheme of the original phenolog studies. Both methods recover held-out genes within a disease at similar rates, but only the hypergeometric score can be compared across diseases. Using a one-year-older release of the graph, the top 100 candidates per disease recovered 9 of 73 gene-disease associations added since, 23.5 times the random-gene expectation. Mouse accounts for most of these, with zebrafish, worm and fission yeast each contributing associations that mouse does not. We release per-disease gene candidate rankings, with known and novel associations flagged, and a dashboard for exploration of our results.
The editor's rubric
- Leverage4 / 5
- A general-purpose tool used across several fields (Adam, ResNet, LoRA, next-generation sequencing).
- Magnitude3 / 5
- Large gain: roughly 2x, or a clear new state of the art on a hard, unsaturated problem.
- Evidence4 / 5
- Strong: large scale, preregistered, independently replicated, or a well-powered randomized trial.
- Novelty3 / 5
- A genuinely new approach to an open problem.
- Trajectory3 / 5
- A clear path to scale.
- Stakes2 / 5
- Benefits a professional community (practitioners, clinicians, engineers).
Editor’s rationale
Heuristic triage from title and abstract text only, not a reading of the paper. Cues found: method (we propose); breadth (many tasks); gains (x-fold); novelty (open problem, discovery); design (randomized); verification (error bars, multiple benchmarks, held-out test); scale (scalable); stakes (genetic disease).
How the score was computed
Desks place stronger verdicts first, then use this score to order work within the same verdict.
- Merit
- 6.7 / 10
- Adjusted merit
- 5.3 / 10
- Attention
- 0%
- Freshness
- 88%