Europe PMC
Verdict: NotableSingle-cell atlas of transcriptomic vulnerability across brain disorders
Neurodegenerative and neuropsychiatric diseases impose a considerable societal and public health burden.
- Cites 5
Biology
Genomes, cells, brains, and the tools that read and write them.
Edition No. 3
Updated UTC
Top stories
1. The Metabolic Organ Clock: A Computable Framework Linking Cell-Lineage Architecture to Emergent Organ Bioenergetics
Cell-type atlases now catalogue hundreds of distinct human cell identities across development, each annotated with mitochondrial abundance, dominant fuel pathway, and lineage of origin, yet no computable model connects…
█████░░░░░4.82. Traversing the solution space of neural networks with Hessian Null Space Continuation
On a single task, deep networks can learn many solutions, depending on their optimizer, training data, architecture, and hyperparameters.
█████░░░░░4.63. A ReAct Agentic AI System for Natural Language Querying and Statistical Analysis of The Cancer Genome Atlas Clinical Data
The Cancer Genome Atlas (TCGA) holds clinical data for over 11,000 patients across 33 cancer types, but access is hard because of complex file structures, heterogeneous formats, and the need for programming.
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More top stories
- bioRxivby Porter, Borkowski
vep-rs: high-throughput Rust variant annotation with population-scale concordance to Ensembl VEP
Summary: Ensembl VEP is the de facto reference for variant consequence annotation, but its Perl implementation limits throughput, and the open reimplementation benchmarked here is ....
No.04Verdict: NotableScore█████░░░░░4.5 - bioRxivby Starko, Coleman, Martone
Universal scaling relationships of marine and terrestrial photoautotrophs with differing developmental trajectories
Backgrounds and Aims: Partitioning of biomass to various organs is fundamental to growth and survival strategies of plant species, with broad-scale ecological implications from ....
No.05Verdict: NotableScore█████░░░░░4.5 - Europe PMCby Zeng, Yang, Prashant N +14
Single-nucleus atlas of cell-type specific genetic regulation in the human brain
Genetic risk variants for common diseases are predominantly located in non-coding regulatory regions and modulate gene expression.
No.06Verdict: NotableScore█████░░░░░4.5
Briefs
- bioRxiv
Planted origin of shade trees: a robust determinant of cocoa yield among smallholder farmers in Cote d'Ivoire
█████░░░░░4.5 - bioRxiv
Biogenic flavonoid capping converts a cytotoxic Carica papaya fraction into a selective, cross-serotype Dengue entry inhibitor
█████░░░░░4.5 - bioRxiv
DS5: An Open-Source Framework for Standardized High-Throughput Drug Screening Data Storage, Analysis, and Drug Prioritization
█████░░░░░4.5 - arXiv
Flattening the Connectome Spectrum: A Spectral Filter for FC Induces a Pretraining Target for fMRI Encoders
████░░░░░░4.5 - bioRxiv
A moving target: non-stationary selection governs unsupervised prediction of viral fitness
████░░░░░░4.5 - bioRxiv
MIMOSA: Guiding De Novo Antibody Design with Natural Interaction Fingerprints
████░░░░░░4.5 - arXiv
LEMON-ZEST: Evolution-Informed Tokenization for Efficient Protein Language Modeling
████░░░░░░4.4 - Science
Method to 'watermark' AI-designed proteins could deter bioweapons, protect scientific credit
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