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Medicine

Trials, therapies, and evidence that changes care.

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Edition No. 26
Updated UTC

Stronger verdicts first · Score orders stories within each verdict

Europe PMC

Verdict: Major

Retatrutide Once Weekly for Treatment of Obstructive Sleep Apnea

Retatrutide, an investigational triple agonist of glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and glucagon receptors, may be useful for treating obstructive sleep apnea (OSA).

By Grunstein, Somers, Azarbarzin +10The New England journal of medicine

Score█████░░░░░5.1

Top stories

  1. 1. Individualized Cardiac Index-Guided Hemodynamic Therapy in High-Risk Patients Undergoing Elective Major Abdominal Surgery: The PELICAN Randomized Clinical Trial

    It remains unclear if intraoperative hemodynamic therapy should be guided by cardiac index.

    Verdict: Major█████░░░░░5.0
  2. 2. Effectiveness of a mHealth nutrition and lifestyle intervention (mHENAL) in reducing Cardiovascular Disease Risk in Sri Lankan adults: A Randomized Control Trial

    Cardiovascular diseases (CVD) are the leading cause of global mortality, responsible for 17.8 million deaths and 423 million prevalent cases annually.

    Verdict: Major█████░░░░░4.6

More top stories

No.03 to No.06

  1. Europe PMCby Oderkerk, Leemans, Beelen +8

    Endometrial ablation plus levonorgestrel-releasing intrauterine system versus endometrial ablation alone in women with heavy menstrual bleeding in The Netherlands (MIRA2): a multicentre, open-label, randomised, controlled, superiority trial

    Endometrial ablation is an established and effective treatment for women with heavy menstrual bleeding, but many patients require further treatment, with approximately 10% ultimately ....

    No.03Verdict: NotableScore█████░░░░░5.0

Briefs

8 more from the desk