Europe PMC
Verdict: NotableSingle-cell atlas of transcriptomic vulnerability across brain disorders
Neurodegenerative and neuropsychiatric diseases impose a considerable societal and public health burden.
- Cites 5
Biology
Genomes, cells, brains, and the tools that read and write them.
Edition No. 4
Updated UTC
Top stories
1. The Metabolic Organ Clock: A Computable Framework Linking Cell-Lineage Architecture to Emergent Organ Bioenergetics
Cell-type atlases now catalogue hundreds of distinct human cell identities across development, each annotated with mitochondrial abundance, dominant fuel pathway, and lineage of origin, yet no computable model connects…
█████░░░░░4.72. Branch-Wise Regularization for Heterogeneous GNN-Based MALDI-TOF AMR Prediction with Biomarker-Consensus Edges
This paper predicts antimicrobial resistance (AMR) from matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectra using DRIAMS, evaluated across 13 species-antibiotic datasets spanning…
█████░░░░░4.73. Evidence Scaling for Zero-Shot Protein Reasoning with Large Language Models
Large language models (LLMs) show emerging zero-shot capability for protein variant prediction, yet still lag behind specialized protein models.
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More top stories
- arXivby Huang, Ostrow, Lu +3
Traversing the solution space of neural networks with Hessian Null Space Continuation
On a single task, deep networks can learn many solutions, depending on their optimizer, training data, architecture, and hyperparameters.
No.04Verdict: NotableScore█████░░░░░4.5 - bioRxivby McKenna, Hemmerling, Nandi +2
Multimodal MRI Clustering Reveals an Elevated Free-Water Biotype in Autism with Increased Social Symptoms
Background: Autism spectrum disorder (ASD) is neurobiologically heterogeneous, and group comparisons may mask effects confined to subgroups.
No.05Verdict: NotableScore█████░░░░░4.5 - bioRxivby Zhang, Li, Zhang +3
AREION: A Foundation Model for Atlas-Agnostic Representation Learning of Brain Connectome
Brain foundation models have shown promising advances in learning generalizable representations from functional magnetic resonance imaging (fMRI) data.
No.06Verdict: NotableScore█████░░░░░4.5
Briefs
- bioRxiv
Rank-Preserving Alignment Enables Cross-platform Learning and Phenotyping for Single-Cell and Spatial Proteomics
████░░░░░░4.5 - Europe PMC
Single-nucleus atlas of cell-type specific genetic regulation in the human brain
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A ReAct Agentic AI System for Natural Language Querying and Statistical Analysis of The Cancer Genome Atlas Clinical Data
████░░░░░░4.5 - bioRxiv
vep-rs: high-throughput Rust variant annotation with population-scale concordance to Ensembl VEP
████░░░░░░4.5 - bioRxiv
T1R2/T1R3 Identified as the Aβ Receptor: A New Mechanism Linking Aβ42/40 Ratio to Neuronal Hyperexcitability in Alzheimer's Disease
████░░░░░░4.5 - bioRxiv
Universal scaling relationships of marine and terrestrial photoautotrophs with differing developmental trajectories
████░░░░░░4.5 - bioRxiv
Planted origin of shade trees: a robust determinant of cocoa yield among smallholder farmers in Cote d'Ivoire
████░░░░░░4.5 - bioRxiv
TRIM21 licenses pancreatic acinar fate by modulating BiP phase state through VCP-dependent retrotranslocation
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