Humanity’s List

Research with real-world weight.

Vol. I · No. 31Updated UTC
Ranked by formula

MedicineEurope PMC

Verdict: Major

Izalontamab brengitecan versus platinum-based chemotherapy in EGFR-mutated advanced non-squamous non-small-cell lung cancer after progression on third-generation EGFR tyrosine kinase inhibitors (PANKU-Lung01): a multicentre, randomised, open-label, phase 3 trial in China

Izalontamab brengitecan (iza-bren) is a first-in-class bispecific antibody-drug conjugate targeting epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 3 (HER3) and has shown…

By Hong, Zhou, Hou +43Lancet (London, England)

Score█████░░░░░5.2

Top stories

  1. MedicineEurope PMC

    1. Izalontamab brengitecan for HR+/HER2- breast cancer in China (PANKU-Breast01): a randomised, phase 3 trial

    Patients with heavily pretreated hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer have few treatment options.

    Verdict: Major█████░░░░░5.1

  2. AIarXiv

    2. Factorized Gradients for Scalable Highly-expressive Parametric Diffeomorphisms

    Diffeomorphisms provide a flexible, topology-preserving mathematical tool for modeling complex spatial or temporal deformations and are used in various scientific fields.

    Verdict: Major█████░░░░░4.7

  3. BiologybioRxiv

    3. Phenologs at knowledge-graph scale: a mouse-to-slime-mold catalog of candidate genes for thousands of human diseases

    Model organisms carry decades of systematic gene-phenotype annotation, but connecting those annotations to human disease is rarely straightforward.

    Verdict: Notable█████░░░░░5.0

  4. ClimatearXiv

    4. Advancing global crop simulations with differentiable modelling

    Verdict: Notable█████░░░░░4.8

  5. PhysicsarXiv

    5. Projected sensitivity to the ADD large extra dimensions model in the monojet plus missing transverse momentum final state at HL-LHC, HE-LHC, and FCC-hh

    Verdict: Notable█████░░░░░4.6

  6. BiologyarXiv

    6. MtReNIRS: A Self-Supervised Foundation Model for Transferable Neurovascular Representations

    Verdict: Notable█████░░░░░4.5

Sections

Artificial Intelligence

Biology

bioRxiv

Design of full-length agonist and antagonist antibodies for hard targets

Therapeutic antibodies have transformed modern medicine, yet conventional discovery relies on lengthy experimental workflows, offers limited control over how antibodies engage their targets, and struggles to deliver…

By Pythia Labs Team, Aglietti, Ansari +15

Verdict: Notable█████░░░░░4.5

Medicine

Climate & Energy

Physics

arXiv

Universal Scaling of the Little-Parks Oscillation Amplitude

The Little-Parks effect played a pivotal role in establishing fluxoid quantization in doubly connected superconductors and providing early evidence for electron pairing, central to BCS theory.

By Shen, Huang, Xu +2

Verdict: Notable█████░░░░░4.5

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