Genomes, cells, brains, and the tools that read and write them.
bioRxiv
Verdict: NotableRNA-binding small molecules represent a validated therapeutic modality, yet pinpointing their exact RNA binding sites remains critical for mechanistic understanding and drug optimization.
Bats are major reservoir hosts of coronaviruses (CoVs), yet the ecological mechanisms governing CoV circulation and cross-species transmission remain poorly understood, particularly in Europe.
Peptide toxicity remains a major bottleneck in drug development, as small sequence variations can drastically alter cytotoxic profiles.
Functional genomics in crops increasingly depends on integrating information from an extensive literature and heterogeneous multi-omics datasets.
The Practical Molecular Optimization (PMO) benchmark standardized evaluation in molecular optimization, but it is built on simple property-based oracles that do not capture ....
Perturbations change both RNA abundance and intracellular organization, but gene-count predictors omit the positions needed to model spatial responses.
Normative models chart how brain measures vary across the lifespan, expressing each individual as a deviation from a healthy reference.