Humanity’s List

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Biology

Genomes, cells, brains, and the tools that read and write them.

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Edition No. 35
Updated UTC

Stronger verdicts first · Score orders stories within each verdict

Europe PMC

Verdict: Major

Izalontamab brengitecan versus platinum-based chemotherapy in EGFR-mutated advanced non-squamous non-small-cell lung cancer after progression on third-generation EGFR tyrosine kinase inhibitors (PANKU-Lung01): a multicentre, randomised, open-label, phase 3 trial in China

Izalontamab brengitecan (iza-bren) is a first-in-class bispecific antibody-drug conjugate targeting epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 3 (HER3) and has shown…

By Hong, Zhou, Hou +43Lancet (London, England)

Score█████░░░░░4.6

Top stories

  1. 1. Decitabine plus busulfan-cyclophosphamide versus busulfan-cyclophosphamide myeloablative conditioning before allogeneic haematopoietic stem cell transplantation for reducing risk of relapse in adult KMT2A‑rearranged leukaemia in China: an open-label, multicentre, randomised phase 3 trial

    An unmet need persists for optimal myeloablative conditioning before allogeneic haematopoietic stem cell transplantation (HSCT) in adult KMT2A‑rearranged leukaemia.

    Verdict: Major█████░░░░░4.7

  2. 2. Advancing morphological profiling with self-supervised learning through comparative insights into representation learning of cellular perturbations

    Self-supervised learning (SSL) enables scalable, label-free foundation models (FMs) that learn task-agnostic representations directly from images, bypassing cell segmentation and feature engineering inherent to…

    Verdict: Notable█████░░░░░4.7

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