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Biology

Genomes, cells, brains, and the tools that read and write them.

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Edition No. 29
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Stronger verdicts first · Score orders stories within each verdict

bioRxiv

Verdict: Notable

Design of full-length agonist and antagonist antibodies for hard targets

Therapeutic antibodies have transformed modern medicine, yet conventional discovery relies on lengthy experimental workflows, offers limited control over how antibodies engage their targets, and struggles to deliver…

By Pythia Labs Team, Aglietti, Ansari +15

Score█████░░░░░4.6

Top stories

  1. 1. Practical Identifiability of a Minimal Adaptive Learning-Gain Model for Binary Feedback: A Simulation Study

    Social learning is jointly determined by several computationally distinct quantities, namely baseline belief (prior mean), sensitivity to feedback (learning gain), and the temporal uncertainty of belief (drift), which…

    Verdict: Notable████░░░░░░4.5
  2. 2. AlphaGenome informed machine learning for pathogenicity prediction of germline mutations

    Accurate interpretation of germline variants remains a central challenge in clinical genomics.

    Verdict: Notable████░░░░░░4.5

More top stories

No.03 to No.06

  1. bioRxivby Wenteler, Neduva, Genes & Health Research Team +3

    Population-scale drug target and variant prioritization with Varformer

    Human genetic variation is a powerful driver of therapeutic target prioritization, yet current models struggle to aggregate variable numbers of variants per gene and are bottlenecked by ....

    No.05Verdict: NotableScore████░░░░░░4.3

Briefs

8 more from the desk