Genomes, cells, brains, and the tools that read and write them.
bioRxiv
Verdict: NotableRNA-binding small molecules represent a validated therapeutic modality, yet pinpointing their exact RNA binding sites remains critical for mechanistic understanding and drug optimization.
Bats are major reservoir hosts of coronaviruses (CoVs), yet the ecological mechanisms governing CoV circulation and cross-species transmission remain poorly understood, particularly in Europe.
Enzyme catalyzed reactions drive metabolism and enable diverse applications in biotechnology and sustainable synthesis, but assigning catalytic functions to uncharacterized enzymes and finding enzymes for target…
The choice of nucleic acid sequence for a given protein strongly impacts function and is species-specific.
Peptide toxicity remains a major bottleneck in drug development, as small sequence variations can drastically alter cytotoxic profiles.
The design of antibody complementarity-determining regions (CDRs) is pivotal for therapeutic development, yet remains challenged by the complexity of the antibody-antigen interface.
The Practical Molecular Optimization (PMO) benchmark standardized evaluation in molecular optimization, but it is built on simple property-based oracles that do not capture ....