Genomes, cells, brains, and the tools that read and write them.
bioRxiv
Verdict: MajorConstructing continuous, thermodynamically reversible reduced equations of motion from atomistic molecular dynamics (MD) that scale from fast-folding miniproteins to multi-domain allosteric enzymes in explicit water…
Izalontamab brengitecan (iza-bren) is a first-in-class bispecific antibody-drug conjugate targeting epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 3 (HER3) and has shown…
Understanding the genetic basis of gene expression can shed light on the regulatory mechanisms underlying complex traits and diseases1,2.
Self-supervised learning (SSL) enables scalable, label-free foundation models (FMs) that learn task-agnostic representations directly from images, bypassing cell segmentation and feature ....
An unmet need persists for optimal myeloablative conditioning before allogeneic haematopoietic stem cell transplantation (HSCT) in adult KMT2A‑rearranged leukaemia.
Tandem repeats (TRs)-highly polymorphic, repetitive sequences across the human genome-are important regulators of gene expression but remain underexplored due to challenges in accurate ....
Model organisms carry decades of systematic gene-phenotype annotation, but connecting those annotations to human disease is rarely straightforward.