Genomes, cells, brains, and the tools that read and write them.
bioRxiv
Verdict: MajorConstructing continuous, thermodynamically reversible reduced equations of motion from atomistic molecular dynamics (MD) that scale from fast-folding miniproteins to multi-domain allosteric enzymes in explicit water…
Understanding the genetic basis of gene expression can shed light on the regulatory mechanisms underlying complex traits and diseases1,2.
Protein Language Models (pLMs) have become essential tools for computational protein analysis, and the rapid proliferation of architectures, training objectives, and pretraining corpora has produced a diverse and…
Inferring how individual patients progress towards higher disease risk typically requires longitudinal observations, which are often unavailable.
Modeling gene regulation in single cells requires jointly representing DNA sequence, chromatin accessibility, and gene expression across regulatory scales.
Biological discovery requires using molecular knowledge and new measurements to infer responses beyond the conditions already observed.
Tandem repeats (TRs)-highly polymorphic, repetitive sequences across the human genome-are important regulators of gene expression but remain underexplored due to challenges in accurate ....