Genomes, cells, brains, and the tools that read and write them.
bioRxiv
Verdict: MajorConstructing continuous, thermodynamically reversible reduced equations of motion from atomistic molecular dynamics (MD) that scale from fast-folding miniproteins to multi-domain allosteric enzymes in explicit water…
Understanding the genetic basis of gene expression can shed light on the regulatory mechanisms underlying complex traits and diseases1,2.
Inferring how individual patients progress towards higher disease risk typically requires longitudinal observations, which are often unavailable.
Biological discovery requires using molecular knowledge and new measurements to infer responses beyond the conditions already observed.
Accurate and reproducible metagenomic analysis is essential for effective infectious disease surveillance.
Self-supervised learning (SSL) enables scalable, label-free foundation models (FMs) that learn task-agnostic representations directly from images, bypassing cell segmentation and feature ....
De novo peptide sequencing has moved from dynamic programming over hand-designed or generative scores to large transformers that learn the task end to end.